What types of peptides does Thinheal supply?

Thinheal supplies generic peptide APIs, therapeutic peptides, GLP-1 analogues such as Semaglutide (CAS 910463-68-2), GLP-2 analogues, other gastrointestinal peptides, other therapeutic peptide APIs and cosmetic peptides for skin-care formulations.

Does Thinheal offer custom peptide development and CDMO services?

Yes. Thinheal provides project-based contract research and development, contract manufacturing and sales support, covering custom peptide development, process optimization, scale-up and commercial API supply through to formulation development.

What is Thinheal's production capacity?

Thinheal operates an R&D center and a production base in Hangzhou, China. Total production capacity for chemically synthesized peptides has reached the multi-ton level.

What documentation can buyers expect?

Each shipment is accompanied by batch analytical data such as a Certificate of Analysis. Additional documents required for supplier qualification or regulatory filings can be scoped with the sales and technical team for each project.

How do international buyers contact the right sales team?

Thinheal runs regional sales desks for USA & Europe, Russia & CIS & Europe, Asia, and the Middle East & East Asia. Buyers can also email info@thinheal.com or call +86 0571-86758863.

High-Quality Vasopressin CAS NO: 50-57-7 Pricelist, Service

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High-Quality Vasopressin CAS NO: 50-57-7 Pricelist, Service

Vasopressin, also known as antidiuretic hormone (ADH) or arginine vasopressin (AVP), is a hormone that plays a crucial role in regulating water and sodium balance in the body. It primarily affects the kidneys, increasing water reabsorption and thus decreasing urine output, and also constricts blood vessels, which can raise blood pressure. Vasopressin is synthesized in the hypothalamus and released from the posterior pituitary gland.

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Product Description

Therapeutic Areas

Human Nervous System: Vasopressin and Cardiovascular Regulation

Vasopressin is a hormone that plays a key role in maintaining osmolality (the concentration of dissolved particles, such as salts and glucose, in the serum) and therefore in maintaining the volume of water in the extracellular fluid (the fluid space that surrounds cells). This is necessary to protect cells from sudden increases or decreases in water content, which are capable of interfering with proper cell function. Normal serum osmolality ranges from about 285 to 300 milliosmoles per kilogram (mOsm/kg) in healthy people. Vasopressin and a hormone called oxytocin evolved from a single primordial neurohypophyseal hormone called vasotocin, which is present in lower vertebrates.

Special nerve cells called osmoreceptors in the hypothalamus are very sensitive to changes in serum osmolality. The osmoreceptors are closely associated with the same nerve cells that produce and secrete vasopressin. Serum osmolality that increases or decreases by as little as 1 percent can cause respective decreases or increases in vasopressin release.

Outlook & Development

This stimulation leads to the separation of vasopressin from molecules of neurophysin, to which vasopressin is loosely attached within the secretory cells. Vasopressin is then released from the posterior pituitary gland, leading to the subsequent retention of water by the kidneys. This inhibition leads to a decrease in vasopressin secretion and a subsequent increase in water excretion. The osmoreceptors are also closely linked to the thirst centre, which is stimulated by high serum osmolality and is inhibited by low serum osmolality in the same way as is vasopressin secretion.

In the kidneys, vasopressin acts on the cells of the collecting ducts. These cells contain receptors for vasopressin that are linked to vesicles that contain special water channels (aquaporins). When the cells are stimulated by vasopressin, the aquaporins fuse with the region of the cell membrane that is exposed to urine, allowing water to enter the cells. The water is then returned to the circulation. This causes the volume of urine to decrease and the urinary content of sodium, chloride, and other substances to increase. When this occurs, the urine is said to be concentrated.

Frequently Asked Questions

Q: What is Vasopressin and what is its primary function?

Vasopressin (also known as ADH or AVP) is a key hormone that regulates water and sodium balance in the body. It promotes water reabsorption in the kidneys and constricts blood vessels to help regulate blood pressure.

Q: Where is Vasopressin synthesized and released in the human body?

Vasopressin is synthesized in the hypothalamus and stored and secreted from the posterior pituitary gland into the bloodstream.

Q: How sensitive is the body to changes in serum osmolality?

The body's osmoreceptors in the hypothalamus are extremely sensitive; a change in serum osmolality of as little as 1% can trigger an increase or decrease in vasopressin secretion.

Q: How does Vasopressin help concentrate urine in the kidneys?

Vasopressin binds to receptors in the collecting duct cells of the kidneys, causing water channels (aquaporins) to fuse with the cell membrane. This allows water to be reabsorbed back into the bloodstream, resulting in lower urine volume and concentrated urinary contents.

Q: What is the evolutionary history of Vasopressin?

Vasopressin and oxytocin evolved from a single primordial neurohypophyseal hormone called vasotocin, which is present in lower vertebrates.